Medicine Cabinet 101: Building Your Fall & Winter Immune Support Plan

Fall is here! Which means back-to-school routines, cooler weather, more time indoors and, inevitably, the return of coughs, colds and other respiratory infections.

For families with young children, managing recurring illness can feel like a full time job. Young children may experience 6–12 upper respiratory tract infections (URTIs) per year, particularly as their immune systems are still developing. As we get older, we tend to get fewer infections, but many adults know the frustration of the lingering cough, fatigue or congestion that seems to stick around long after the original illness has passed.

The good news? While most colds and uncomplicated respiratory infections are self-limiting and resolve with time, there are evidence-informed strategies that can help support immune function, reduce your risk of getting sick and potentially make some illnesses shorter or more manageable.

The key is having the right things in your medicine cabinet before you need them.

Start with the basics

Before reaching for supplements, think about healthy habits and the foundations of immune health:

  • Staying up to date with recommended vaccinations

  • Hand washing with soap

  • Masking when appropriate (travel, crowds, etc)

Sleep plays an important role in immune regulation and recovery. If you're consistently running on five hours a night, adding another supplement isn't likely to make up the difference. Aim for a consistent sleep schedule and give yourself enough time in bed to feel rested.

Regular physical activity supports overall immune health. The goal isn't to train harder when you're already run down — it's to maintain regular, moderate activity while allowing your body adequate recovery. For athletes and people exercising at high volumes, adequate nutrition and calorie intake are particularly important. Chronic under-fuelling can place additional stress on the body and may negatively affect immune function.

Protein at each meal. Your immune system requires amino acids to build antibodies and other immune proteins. Make sure your meals regularly include protein sources such as eggs, fish and seafood, chicken and turkey, greek yogurt or other dairy, tofu and tempeh, beans and pulses.

Fruits and vegetables provide vitamins, minerals, fibre and polyphenols that support overall health and immune function. Aim for variety and colour rather than searching for one magic immune-boosting food.

Avoid alcohol and tobacco. Reducing or eliminating these habits is one of the most impactful things you can do for your overall health — including your respiratory health.

Start where you are and get support along the way.

Your medicine cabinet: what is actually worth having on hand?

There are several evidence based immune support supplements to consider, but they don't all work in the same way.

One of the most important distinctions is prevention versus treatment. Something that may help reduce the likelihood of getting sick isn't necessarily the same thing that helps once you're already coughing and congested.

For prevention

Vitamin D

Vitamin D plays an important role in immune function, as well as bone, muscle, metabolic and mental health. Assessing vitamin D through a simple blood test can be useful when there is a clinical reason to suspect deficiency. Supplementation may be necessary year round, or at least during months with limited sun exposure.

Echinacea

Echinacea is one of the more extensively studied herbal medicines for respiratory infections. Pooled results estimate a ~30% reduction in risk of upper respiratory tract infections in otherwise well adults and children. Trials also show low adverse events, lower use of antibiotics and fewer daycare/workdays missed with use.

A bit of science to share for families with kids — the number needed to treat (NNT) for echinacea is 4, meaning only 4 children need to take echinacea to prevent one respiratory tract infection — which is considered exceptional in the world of evidenced based interventions.

Already sick? A few options to consider

Once the illness has arrived, the goal changes. We're generally looking at ways to support recovery and manage symptoms. In addition to pain and fever reducing tools, you may want to consider the following:

Elderberry

Elderberry (Sambucus nigra) has some of the more promising evidence among natural products for reducing the duration or severity of upper respiratory symptoms.

Pooled research has shown that elderberry reduces the number of symptom days for upper respiratory tract infections by 2-3 days. Elderberry is particularly useful for improving systemic symptoms such as fever and malaise and in one small trial was comparable to Tamiflu (a prescription antiviral for flu) in effect.

This one also comes in a syrup that tastes great and is safe for kids and adults.

English ivy leaf

English ivy leaf (Hedera helix) is the best studied herbal medicine for cough associated with respiratory infections and has established safety profiles in all ages, from infants to the elderly.

We have evidence of benefit in reducing cough severity and improving sleep disturbance due to cough. There are a number of formulations available, including syrups designed for children that taste pretty good!

English ivy has replaced honey as my go to for cough in children and adults, based on the strength of evidence and ease of use.

N-acetyl cysteine (NAC)

N-acetyl cysteine (NAC) is a precursor to the antioxidant glutathione and has mucolytic properties, meaning it can help make thick mucus easier to clear.

Research has investigated NAC for a variety of respiratory conditions, and it may be particularly useful when a cough is wet and mucus-producing rather than dry and irritated. I tend to reserve this option for adults as it mostly comes in capsulated form.

Zinc

Zinc may modestly shorten the duration of a cold when started very early — ideally around the onset of symptoms.

More isn't necessarily better. High doses on an empty stomach can cause nausea and other adverse effects, and prolonged high-dose zinc can interfere with copper status.

You may want to use zinc lozenges, capsules or powders, depending on your age and preferences.

Beta-glucans

Beta-glucans are naturally occurring compounds found in foods and fungi, including mushrooms such as oyster mushrooms.

Some research suggests that specific beta-glucan preparations may influence immune responses and potentially reduce both the frequency and severity of respiratory infections. Pooled results also show a reduction in missed school days and antibiotic use, with particular evidence highlighting benefits in immune challenged populations, including children with asthma, athletes, and the elderly.

As with all natural health products, the specific preparation matters, so results from one product shouldn't automatically be applied to every mushroom supplement.

Final thoughts

Not every illness can be managed at home without further medical interventions. More supplements doesn't necessarily mean better immune support.

The best approach is individualized. Age, medications, pregnancy, chronic conditions, allergies and the specific symptoms you're experiencing can all change which products are appropriate — and which ones aren't.

Want to build your own immune-support plan?

Rather than waiting until everyone in the household is sick, fall is a great time to take a look at what's already in your medicine cabinet and create a plan for the season ahead.

New patients can book an initial consultation with me on Tuesdays or Thursdays. If you've worked with me before, you can also book a 45-minute follow-up appointment to create an individualized fall/winter immune-support action plan — including what to keep on hand, when to use it and what to skip.

Because the goal isn't to take everything. It's to know what you need, when you need it, and why.

References

Benedetti F, Santus P. N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. Drugs Context. 2025 Nov 13;14:2025-7-7. doi: 10.7573/dic.2025-7-7. PMID: 41312188; PMCID: PMC12657002.

Gancitano G, Mucci N, Stange R, Ogal M, Vimalanathan S, Sreya M, Booker A, Hadj-Cherif B, Albrich WC, Woelkart-Ardjomand K, Kreft S, Vanden Berghe W, Hoexter G, Schapowal A, Johnston SL. Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA). Antibiotics (Basel). 2024 Apr 16;13(4):364. doi: 10.3390/antibiotics13040364. PMID: 38667040; PMCID: PMC11047471.

Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019 Feb;42:361-365. doi: 10.1016/j.ctim.2018.12.004. Epub 2018 Dec 18. PMID: 30670267.

Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, Diamant Z, Majtan J, Emeryk A. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025 Feb 28;15(1):7146. doi: 10.1038/s41598-025-91830-2. PMID: 40021713; PMCID: PMC11871075.

Kow CS, Ramachandram DS, Hasan SS, Thiruchelvam K. Effect of N-Acetylcysteine on mortality in COVID-19 patients: A systematic review and meta-analysis. Inflammopharmacology. 2025 Aug;33(8):4871-4877. doi: 10.1007/s10787-025-01876-x. Epub 2025 Jul 29. PMID: 40728675.

Mazi A, Alqahtani RM. Role of Echinacea in the management and prevention of acute respiratory tract infections in children: A systematic review of the evidence. J Family Community Med. 2025 Oct-Dec;32(4):273-283. doi: 10.4103/jfcm.jfcm_144_25. Epub 2025 Oct 17. PMID: 41234257; PMCID: PMC12611053.

Mokra D, Porvaznik I, Mokry J. N-Acetylcysteine in the Treatment of Acute Lung Injury: Perspectives and Limitations. Int J Mol Sci. 2025 Mar 15;26(6):2657. doi: 10.3390/ijms26062657. PMID: 40141299; PMCID: PMC11942046.

Trompetter I, Braun S. Efficacy and Safety of Ivy Leaf Dry Extract EA 575 in Cough Management: An Updated Review of Clinical Evidence. Planta Med. 2026 Jul;92(8):774-789. doi: 10.1055/a-2743-1130. Epub 2026 Jan 23. PMID: 41576988; PMCID: PMC13349513.

Sierocinski E, Holzinger F, Chenot JF. Ivy leaf (Hedera helix) for acute upper respiratory tract infections: an update


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